Fluke

Matthew Modine

Thomas P. Johnson / Voice of Fluke

Nancy Travis

Carol Johnson

Eric Stoltz

Jeff Newman

Max Pomeranc

Brian Johnson

Ron Perlman

Sylvester

Jon Polito

Boss

Bill Cobbs

Bert

Federico Pacifici

Prof. Santini

Clarinda Ross

Jane, Tom's Secretary

Adrian Roberts

Night Guard

Bart Hansard

Day Guard

Deborah Hobart

Dogpound Vet

Libby Whittemore

Libby, the Housekeeper

Collin Wilcox Paxton

Bella

Samuel L. Jackson

Rumbo (voice)